Localised oral amyloidosis in the context of oral epithelial dysplasia: Literature review and report of two cases

Amyloidosis is a group of rare progressive diseases that occur as result abnormal protein folding and aggregation. Systemic amyloidosis serious disease with high mortality, prompt diagnosis key to improving prognosis. Conversely, localised does not reduce life expectancy can often be treated simple surgical excision. Amyloid deposits found in the oral cavity, usually context systemic amyloidosis. We present two cases acquired immunoglobulin light chain (AL) were detected biopsies taken for management epithelial dysplasia (OED). Both patients underwent thorough multisystem investigations by haematology conjunction NHS National Centre (NAC) order exclude confirm diagnosis. Localised rare, our knowledge, AL has been reported OED before. discuss important learning points from these well hypothesising on pathophysiology involved.